MEETINGS & EVENTS

Novel Techniques and Innovation in Blood Purification (2011)

KDIGO Controversies Conference: Novel techniques and innovation in blood purification: How can we improve clinical outcomes in hemodialysis?

Paris, France, October, 2011

(Conference Report Pending)

Background:
Kidney Disease Improving Global Outcomes (KDIGO) is an international organization whose mission is to improve the care and outcomes of kidney disease patients worldwide by promoting coordination, collaboration, and integration of initiatives to develop and implement clinical practice guidelines. Periodically, KDIGO sponsors conferences on topics of importance to patients with kidney disease. These conferences are designed to review the state of the art on a focused subject, and to ask conference participants to determine what needs to be done in this area to improve patient care and outcomes. Sometimes the recommendations from these conferences lead to KDIGO guideline efforts, but other times they highlight needed areas for additional research to produce evidence that might lead to guidelines in the future.

The recent interest in novel techniques and innovation in blood purification was born out of the impasse in an effort to improve survival and quality of life of patients with end-stage renal disease (ESRD). Although there have been medical and technical advances, mortality rate of patients with ESRD remains inappropriately elevated at about 10 - 20% per year. There have been a number of recent clinical trials and technical advances that suggest potential solutions to improve outcomes in dialysis.

To further elucidate these potential improvements in dialysis, KDIGO sponsored a conference on “Novel techniques and innovation in blood purification: How can we improve clinical outcomes in hemodialysis?” The conference was held on 14-15 October, 2011 in Paris, France. Drs. Christopher Chan, Nathan Levin and Francesco Locatelli co-chaired the conference, which focused on three themes: (1) dialysis technique, (2) dialysate composition and (3) technical innovation in blood purification and bio-engineering. Invited participants and speakers included the leading worldwide experts in these topic areas, including nephrologists, bio-engineers, and industry representatives to give the broadest views possible on the subject. Their task was to summarize the existing knowledge, develop recommendations on what can be done to optimize outcomes in dialysis patients based on this knowledge, and to formulate and prioritize research questions to enhance our knowledge base on renal replacement therapy. The conference output will include publication of a position statement.

• Click here for the complete description and agenda from the conference ( )
  
• Click here for the roster of conference participants ( )
  

PLENARY SESSION PRESENTATIONS

Plenary Sessions: Dialysis Techniques

Hemodialysis Modality – Frequency, Duration, Location ()
Presenter:  Jonathan Craig

Hemodiafiltration ()
Presenter: Bernard Canaud
 
Uremic Toxins and Molecules of Choice ()
Presenter: Raymond Vanholder

Monitoring of Dosing Regimen ()
Presenter: Thomas Depner

Plenary Sessions: Innovation in Process of Care

Calcium Load – Dialysate Concentration, Vit D and Phosphate Binders ()

Presenter: Frank Gotch

Differences in Survival – Lessons learned from Registries

• USRDS 
  Presenter: Allan Collins ()

• DOPPS 
  Presenter: Bruce Robinson

Technical and clinical barriers to implementing an optimal case mix of vascular access 
Presenter: Louise Moist

Models of chronic kidney disease care and initiation of dialysis ()
Presenter:  Paul Stevens

International variation in the use of intensive renal replacement therapy – barriers versus incentives (DOPPS) 
Presenter: Ronald Pisoni

Supportive Care versus Dialysis in the Aged 
Presenter: Vanita Jassal ()

Prevention of cardiovascular morbidity in HD patients: the role of therapeutics versus dialysis technique

• Therapeutics/Pharmacology 
  Presenter: Christoph Wanner ()
• Dialysis Techniques 
  Presenter: Ercan Ok ()

Plenary Sessions: Technical Advances in Blood Purification and Bio-engineering

Debate: Do advances in hemodialysis technology (e.g. the use of biofeedback, blood volume and clearance monitoring) offer better outcomes?

• Pro: Antonio Santoro ()
• Con: Peter Kerr   ()

Alternate Dialysis Platforms:

• Sorbents 
  Presenter: Norma Ofsthun ()

• Nanotechnology 
  Presenter: William Fissell ()

• Microfluidics 
  Presenter: Edward Leonard

• Wearable kidney system 
  Presenter: Victor Gura ()

• Bioartificial kidney system 
  Presenter: H. David Humes   ()

Use of cell therapy and biomedical engineering in vascular access 
Presenter: Prabir Roy-Chaudhury ()