Mission Statement:

To improve the care and outcomes of kidney disease
patients worldwide through promoting coordination,
collaboration and integration of initiatives to develop
and implement clinical practice guidelines.

Tables, figures, and algorithms
TABLES
S8 Table 1. Prevalence of HCV infection in hemodialysis patients from various countries
S16 Table 2. Summary Table of baseline characteristics of hemodialysis patients tested for HCV (EIA vs. NAT)
S17 Table 3. Summary Table of testing for HCV in hemodialysis patients (EIA vs. NAT)
S19 Table 4. Evidence Profile for diagnostic testing for HCV in hemodialysis patients
S26 Table 5. Recommended treatment of HCV infection in patients with CKD and their associated adverse events
S27 Table 6. Ribavirin dosing based on creatinine clearance and targeted steady-state concentration of ribavirin
S31 Table 7. Monotherapy with conventional interferon in dialysis patients
S32 Table 8. Summary Table of baseline characteristics of hemodialysis patients with chronic HCV infection receiving IFN-based regimens
S33 Table 9A. Summary Table of IFN-based regimens in hemodialysis patients with chronic HCV infection: main outcomes
S36 Table 9B. Summary Table of IFN-based regimens in hemodialysis patients with chronic HCV infection: other outcomes described
S37 Table 10. Evidence Profile of treatment with interferon-based regimens in hemodialysis patients with chronic HCV infection
S38 Table 11. Summary Table of baseline characteristics of kidney transplant recipients with chronic HCV infection receiving therapy
S39 Table 12. Summary Table of treatment in kidney transplant recipients with chronic HCV infection
S40 Table 13. Summary Table of adverse events leading to discontinuation of treatment in kidney transplant recipients with chronic HCV infection
S41 Table 14. Evidence Profile for treatment regimens in kidney transplant recipients with chronic HCV infection
S43 Table 15. Summary Table of pegylated-interferon monotherapy in hemodialysis patients with chronic HCV infection
S44 Table 16. Summary Table of pegylated interferon plus ribavirin in hemodialysis patients with chronic HCV infection
S45 Table 17. Evidence Profile for treatment with pegylated-interferon monotherapy or pegylated interferon plus ribavirin in hemodialysis patients with chronic HCV infection
S47 Table 18. Hygienic precautions for hemodialysis (general)
S48 Table 19. Hygienic precautions for hemodialysis (dialysis machines)
S51 Table 20. Summary Table of virologic investigations of HCV outbreaks in hemodialysis units
S52 Table 21. Summary Table of epidemiologic investigations of HCV outbreaks in hemodialysis units
S66 Table 22. Summary Table of patient mortality in HCV-positive kidney transplant recipients vs. wait-listed HCV-positive hemodialysis patients
S67 Table 23. Summary Table of adjusted mortality and graft loss in HCV-positive vs. HCV-negative kidney transplant recipients
S68 Table 24. Summary Table of outcomes following kidney transplantation using HCV-positive donors
S73 Table 25. Summary Table of baseline characteristics of patients treated for HCV-associated glomerular disease
S74 Table 26. Summary Table of effect of treatment of HCV-associated glomerular disease
S76 Table 27. Summary Table of adverse events of treatment in HCV-associated glomerular disease
S77 Table 28. Evidence Profile for effect of treatment of HCV-associated glomerular disease
S79 Table 29. Histologic scoring systems of liver fibrosis
S81 Table 30. Systematic review topics and screening criteria
S82 Table 31. Literature search yield of primary articles for systematic review topics
S83 Table 32. GRADE system for grading quality of evidence
S84 Table 33. Balance of benefit and harm
S84 Table 34. Levels of strength of recommendations
FIGURES
S13 Figure 1. Summary receiver operating characteristic curve: EIA vs. NAT
S13 Figure 2. Probability of HCV infection based on population prevalence and EIA test accuracy
ALGORITHMS
S10 Algorithm 1. CKD Stage 5 hemodialysis diagnostic algorithm
S53 Algorithm 2. Pretransplant evaluation for HCV infection
S54 Algorithm 3. Management of the wait-listed pretransplant candidate